The film starts with a freak accident, where Max, Sophie and Gus of the Space Protection Force, and their microscopic spaceship the SPF50, take up residence inside 14-year-old Norman’s brain. They can see what he sees and hear what he hears. The nanosized crime fighting aliens must enlist Norman’s help to save earth from Zolthard, an evil intergalactic villain who has taken control of principal Witherington. Norman and the aliens, together with his friends from school must go to great lengths to conceal the presence of alien life at their high school, all the while fighting the galactic struggle between good and evil. After all, Zolthard still has a school to run, and Norman still has a life to live and homework to hand in!